This revolutionary hydrogen inhalation system is designed to provide a controlled and consistent fraction of inspired hydrogen (FiH₂) by utilizing an inflatable reservoir bag. The system delivers a total gas flow rate of approximately 12 L/min, ensuring that individuals with a minute ventilation at or below this threshold receive a precise FiH₂ within the selected and ideal range (0.5 - 4% H₂).
Delivers precise hydrogen concentration
Every inhalation delivers a beneficial physiological effect
Safest hydrogen delivery system on the market
Key Features & Benefits
Inflatable reservoir bag ensures every breath taken contains intended FiH₂, mitigating variability associated with other direct H₂ flow adjustments
Adjustable hydrogen flow rate provides precise control over H₂ delivery, accommodating different research parameters and physiological conditions
Total flow rate of ~12 L/min maintains stable FiH₂ regardless of variations in breathing patterns, tidal volume, or inhalation depth
Designed to limit safety risks by delivering efficacious amounts of hydrogen without exceeding 4% FiH₂. Levels above this range introduce safety risks, including the potential for hypoxia and flammability concerns.
Wellness Promoting Considerations and FiH₂ Requirements
The effectiveness of hydrogen is dependent on reaching a sufficient concentration of H₂ in cells. Based on leading research, a minimum intracellular H₂ concentration of approximately 5–10 µM is suggested for biological effects to occur. This corresponds to an FiH₂ of at least 1%.
FiH₂ below 1% may not consistently achieve intracellular concentrations necessary for beneficial effects.
Higher FiH₂ concentrations (e.g., 2–4%) can more reliably elevate tissue H₂ levels within the beneficial range.
Exceeding 4% FiH₂ introduces safety risks, including the potential for hypoxia and, more critically, flammability concerns.
Understanding FiH₂, Flow Rate Selection, and Flammability Risks
Achieving a target FiH₂ requires consideration of individual respiratory dynamics.
Hydrogen inhalation delivery systems without a controlled total flow rate face significant variability in FiH₂ due to fluctuations in breathing frequency, inhalation volume, and exhalation patterns, and thus less efficacious results.
A direct H₂ flow of 200 mL/min to several liters per minute may be required to achieve an FiH₂ of 4%, depending on individual ventilation rates, and most clinical and research environments prohibit hydrogen inhalation devices exceeding 4% FiH₂ due to these safety concerns.
Our inflatable reservoir system ensures stable FiH₂ within a safe and controlled range, optimizing wellness-promoting potential while adhering to safety and regulatory standards.
Regulatory and Clinical Considerations
Most hospitals, clinics, and research institutions follow strict safety guidelines that prohibit hydrogen inhalation systems exceeding 4% FiH₂. This device is designed to comply with these restrictions while providing reliable and reproducible hydrogen delivery.
